By Max J. Coppes M.D., Ph.D., Christine E. Campbell Ph.D., Bryan R. G. Williams Ph.D. (auth.)

WT1 is a DNA Binding Protein Containing 4 C2H2 Zinc arms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 The DNA Binding area ofWT1 ··············································~··· ninety WT1 Inhibits Tag and SV40 starting place established Replication . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ninety seven WT1 is an strange C2H2 Zinc Finger Protein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ninety eight WT1 is a Transcriptional Regulator . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ninety nine attainable Downstream objectives ofWT1 Transcriptional law . . . 103 Protein-Protein Interactions related to WT1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104 different components which may give a contribution to or adjust the mobile functionality ofWT1 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104 WT1 and Apoptosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106 end . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 7. evidently taking place Mutations within the WTJ Gene . . . . . . . . . . . . . . . . . . 113 creation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 WTI Mutations in Wilms Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 114 research of WTI Mutations in Tumors except Wilms Tumor . . . 122 Constitutional WTI Mutations and the Denys-Drash Syndrome . . . . . . a hundred twenty five end . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131 eight. different Loci Implicated in Wtlms Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 advent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 137 Nephrogenic Rests, WTI Mutations and Wilms Tumor . . . . . . . . . . . . . . . . . . . 137 Undetectable WTI Mutations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138 Wilms Tumor and WITI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . a hundred and forty lack of Heterozygosity for Chromosome 1 p and 16q . . . . . . . . . . . . . . . . . . . . . . . . 141 Wilms Tumor and Beckwith-Wiedemann Syndrome . . . . . . . . . . . . . . . . . . . . . . . . 141 Wilms Tumor and Perlman Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . one hundred forty four Imprinting, IGF/l, HI9 and Wilms Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . one hundred forty four Wilms Tumor and Li-F raumeni Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149 Familial Wilms Tumor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149 Wilms Tumor and different disorder institutions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . a hundred and fifty end . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . one hundred fifty Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 7 =====PREFACE===== ilms tumor is a typical pediatric neoplasm of the kidney which has been W thought of a paradigm for figuring out the etiology of embryonal tu­ mors.

Show description

Read or Download Wilms Tumor: Clinical and Molecular Characterization PDF

Similar Clinical books

Atlas of Emergency Medicine

This complete photograph atlas identifies the various stipulations for which visible cues considerably advisor or expedite prognosis, therapy and disposition within the emergency division. a quick accompanying textual content contains: description, prognosis, linked stipulations, medical pearls, differential prognosis, ED therapy and disposition and references.

Advances in Clinical Chemistry (Volume 46)

Quantity forty six within the across the world acclaimed Advances in scientific Chemistry includes chapters submitted from prime specialists from academia and scientific laboratory technology. Authors are from a various box of scientific chemistry disciplines and diagnostics starting from easy biochemical exploration to state-of-the-art microarray know-how.

Additional info for Wilms Tumor: Clinical and Molecular Characterization

Show sample text content

Rated 4.50 of 5 – based on 15 votes