By Neal Lewin, Mary Ann Howland
The such a lot depended on, rigorous, and up to date toxicology source and academic significant other on hand – now in complete color
A Doody's center name crucial buy for 2011!
Goldfrank’s Toxicologic Emergencies is still the resource you could flip to first for any poisoning or overdose. The textual content offers transparent info on each element of toxicologic emergencies, from pharmacology to scientific presentation to management.
Fully referenced and that includes a constant association, Goldfrank’s starts off with an in-depth exam of basic rules of scientific toxicology. It then progresses to the biochemical rules and molecular foundation of toxicology, and gives designated perception into how xenobiotics have an effect on very important symptoms, organs, and platforms in the course of the physique. subsequent, a large spectrum of clinically very important exposures -- together with medications, vegetation, metals, family items, occupational and environmental xenobiotics are coated inside of logical different types for simple entry to details. ultimately, the ebook concludes with sections on rules of training scientific toxicology in today’s demanding healthcare environment.
NEW TO THIS EDITION
- Full-color layout and uniformly drawn figures make clear key innovations
- Special concerns specialise in decision-making in special toxicologic situations, that impact medical perform and feature the aptitude to enhance sufferer care
- Antidotes extensive, following pertinent chapters, position every one antidote in its right context to make sure quick availability of crucial info proper for medical use
- More clinically-relevant figures and quick-reference tables
- Online studying heart, on hand at www.goldfrankstoxicology.com, comprises case reports, and a database of a number of selection questions that let you create a customized try out for assessment and examine.
- Every bankruptcy is punctiliously rewritten and new chapters are further to mirror the very most up-to-date pondering within the field
Human biomonitoring has constructed from a examine instrument in occupational and environmental future health to spot and quantify exposures to destructive elements in urine and blood. The analytical tools for detection of drugs in organic media have significantly better with smaller detection limits and extra specific and particular measurements. Human biomonitoring is a useful instrument in publicity estimation of chosen populations and at the moment utilized in surveillance courses world wide. This quantity set offers an outline of present on hand biomarkers and human biomonitoring courses in environmental future health, that is well timed given the current debate on opposed well-being results from environmental exposures. The books decribe either earlier and ongoing reviews in addition to the more moderen biomarkers of publicity and results. quantity one describes present human biomonitoring courses in Germany, Romania, France, Canada, India and Belgium, offering convincing proof of a world decline in human exposures to guide and lengthening trouble from publicity to endocrine disruptors and the genotoxic compound. Biomarkers of particular exposures to quite a lot of widespread daily compounds resembling phthalates, PFCs, bisphenol A, brominated flame retardants, PAHs, dioxins, mercury and arsenic also are mentioned. quantity decribes human biomonitoing of exposures to environmental tobacco smoke, mycotoxins, physiological pressure, hormone task, oxidative tension and ionizing radiation, in addition to impression biomarkers of hemoglobin adducts, germ cells, micronuclei and person susceptability. The books could be crucial interpreting for toxicologists, environmental scientists and all these operating within the defense and hazard evaluate of chemical compounds.
Arsenic, antimony and bismuth, 3 similar components of crew 15, are all present in hint amounts in nature and feature fascinating organic houses and makes use of. whereas arsenic is foremost as a poison - and certainly the illness of groundwater by means of arsenic is turning into a tremendous illness in Asia - it additionally has makes use of for the therapy of blood melanoma and has lengthy been utilized in conventional chinese language medication. Antimony and bismuth compounds are utilized in the health facility for the remedy of parasitic and bacterial infections.
Biological Chemistry of Arsenic, Antimony and Bismuth is an important evaluation of the organic chemistry of those 3 components, with contributions from a world panel of specialists. themes lined include:
- chemistry of As, Sb and Bi
- biological chemistry of arsenic
- biological chemistry of Sb and Bi
- arsenic and antimony speciation in environmental and organic samples
- arsenic in conventional chinese language medicine
- arsenic in aquifers
- biomethylation of As, Sb and Bi
- uptake of metalloids via cells
- bismuth complexes of porphyrins and their strength in scientific applications
- Helicobacter pylori and bismuth
- metabolism of arsenic trioxide in blood of the extreme promyelocytic leukemia patients
- anticancer homes of As, Sb and Bi
- radio-Bi in melanoma therapy
- genotoxicity of As, Sb and Bi
- metallomics as a brand new method for As, Sb and Bi
- metalloproteomics for As, Sb and Bi
Biological Chemistry of Arsenic, Antimony and Bismuth conveys the basic features of the bioinorganic chemistry of those 3 parts, making this e-book a priceless supplement to extra common bioinorganic chemistry texts and extra really expert topical experiences. it is going to discover a position at the bookshelves of practitioners, researchers and scholars operating in bioinorganic chemistry and medicinal chemistry.
Presents an replace on numerous new facets of peroxisome biology, together with the function of the peroxisome proliferator activated receptor. The booklet covers morphilogical, biochemical and molecular organic points of peroxisomes.
Because the pioneering discoveries of Hodgkin, Huxley, and Katz, it's been transparent that categorical ion conductance pathways underlie electric act- ity. Over the resultant 50 years, there was ever expanding, and occasi- best friend explosive, alterations within the scope of efforts to appreciate ion channel habit. The advent of patch clamp know-how by means of Erwin Neher and Bert Sakmann approximately twenty years in the past resulted in the belief of the good number of novel ion channel species, and the next revolution in cl- ing has published a good larger variety of the underlying molecular entities. this present day, advances within the research of ion channel constitution and serve as c- tinue at a excessive velocity, from angstrom solution imaging of crystallized ch- nels to their genetic manipulations in animals. during this regard, the sphere is a balanced person who inquires not just what ion channel entities are there, or how they function, but in addition the place are those molecular digital switches? even though, this stability isn't really relatively good awarded to the final sci- tific viewers or to experts within the box. there are many really good and helpful books and monographs, in addition to meetings and conferences on v- tually each element of ion channel constitution and serve as. although, we're unaware that the channel localization subject has been thought of in a u- fied discussion board.
Dermal (percutaneous epidermis) absorption is a world time period that describes the delivery of chemical compounds from the outer floor of the surface either into the surface and into the systemic circulate. Dermal absorption can happen from occupational environmental or purchaser dermis publicity to chemical compounds cosmetics and pharmaceutical items.
This new quantity within the Environmental future health standards sequence provides an summary of dermal absorption and its attention within the danger evaluate of chemical compounds. It describes the equipment on hand to evaluate dermal absorption the importance of dermis as a direction of publicity and the translation of result of dermal absorption reviews for possibility review. moreover it provides and discusses present issues of curiosity within the box of dermal absorption. This booklet could be helpful to biology and toxicology scientists and researchers in addition to to regulatory experts and the chemical industry.
The previous couple of years have caused many adjustments within the box of marine and freshwater pollution, with advances in analytical know-how and the belief that those pollutants are an international factor. delivering an entire reference advisor, Seafood and Freshwater pollutants: Pharmacology, body structure, and Detection, 3rd Edition addresses all elements of the social and clinical impact of phytotoxins, from laws and tracking to new drug improvement. overlaying many new subject matters, the booklet examines 3 major elements: tracking of poisons; chemical, mechanistic, and toxicological variety; and detection technologies.
New to this edition:
- 35 new chapters and five up-to-date chapters
- A specialise in cutting-edge methodology
- Coverage of latest applied sciences to domesticate algae and to spot, isolate, and quantify toxins
- Regulatory changes
- Climate swap evidence
- Expanded details on toxicology
Part I of the e-book comprises an outline and stories normal concerns with regards to toxin detection, ecology, and variety, and results of weather swap. half II covers affects of poisons concerning epidemiology, toxicology, economics, and surveillance. half III explores to be had detection applied sciences, similar to sensible assays, biosensors, mass spectrometry, nanotechnology, and extra. additionally, average reference fabrics for pollutants are mentioned. components IV to VI supply precise descriptions of toxin chemical variety, organic resources, and modes of motion. half VII addresses using pollution as beginning issues for healing medications for melanoma, neurological problems, and for novel antibiotics.
By Nick H. Proctor
The critical source for healthiness execs on probably damaging chemicals--now absolutely updated
Proctor and Hughes' Chemical risks of the place of work, 5th version offers a finished reference textual content for healthiness execs who want toxicology information on chemical compounds which may be encountered in a number of paintings settings. development at the good fortune of the Fourth Edition-already a typical text-this re-creation updates and revises the greater than six hundred entries of that textual content, and in addition provides monographs on new compounds.
Introductory chapters conceal toxicological options, scientific manifestations of publicity, the analysis of occupational affliction, and commercial hygiene facets of chemical exposures. the remainder of the textual content comprises greater than 625 alphabetically prepared entries on person compounds, every one of which includes:
* Chemical formula
* CAS number
* 2003 ACGIH (American convention of presidency business Hygienists) threshold restrict value
* actual properties
* assets of exposure
* Routes of exposure
* Toxicological data
The toxicological information contains either acute and protracted results, specially as with regards to any recognized publicity degrees. the knowledge emphasizes human experiences and instances over animal info each time adequate details is obtainable, and addresses any recognized carcinogenic, mutagenic, fetotoxic, or different reproductive results. scientific info is gifted in a succinct narrative shape to help in understanding.
effortless to take advantage of, in-depth, and finished, Proctor and Hughes' Chemical dangers of the office, 5th variation bargains occupational well-being physicians, nurses, commercial hygienists, and different safeguard execs a useful and updated source.
During the last decade, there were significant advances in realizing the mechanisms wherein marijuana interacts with the mind in generating psychoactive and possibly healing results. the invention of particular gene coding for cannabinoid receptors activated via smoking marijuana, and the discovering of endogenous cannabinoids, which additionally turn on the receptors, have reworked cannabinoid examine into mainstream technological know-how with major implications in human wellbeing and fitness and illness
Endocannabinoids: The mind and Body’s Marijuana and past documentsadvances within the discovery and functioning of evidently happening marijuana-like components in human biology. It explores fresh findings that time to the lifestyles of an endocannabinoid physiological keep watch over method (EPCS) that at once affects human improvement, healthiness, and disorder. whereas cannabinoid results at the mind have got the best consciousness during the literature, this paintings seems at learn at the endogenous cannabinoid system’s organization throughout all of human body structure, together with the immune, endocrine, and reproductive platforms.
With completely researched and particularly insightful contributions from greater than three-dozen top-flight researchers representing a cross-section of disciplines from molecular biology, genetics, and neurology to gynecology, body structure, and pharmacology, this paintings explores quite a number subject matters as large because the human physique is complicated. those subject matters contain the EPCS’s relation to mobile improvement and law, CNS functionality, immune functionality modulation, copy, and digestion, in addition to its functionality in psychological ailment, neurodegenerative ailments, and melanoma.
The ultimate part within the booklet considers the importance of endogenous cannabinoids present in a few of the least difficult multicellular organisms within the animal country, in addition to in mammalian cells on the earliest levels of improvement, all of which means that they play a basic function in human biology.
Enocannabinoids: The mind and Body’s Marijuana and past explores components that few books have ventured into, supplying state-of-the-art details that would finally aid us greater comprehend human biology on the systemic and maybe even mobile point, in addition to result in the improvement of a complete new variety of medications.
By Robin Chowdhury
Freshly up-to-date and prolonged model of Slope research (Chowdhury, Elsevier, 1978). This reference ebook supplies a whole review of the advancements in slope engineering within the final 30 years. Its multi-disciplinary, severe method and the chapters dedicated to seismic results and probabilistic methods and reliability analyses, mirror the particular kind of the unique. matters mentioned are: the certainty of slope functionality, mechanisms of instability, standards for modeling and research, and new concepts for commentary and modeling. detailed recognition is paid to the relation with the expanding frequency and outcomes of common and man-made dangers. concepts and strategies for assessing landslide susceptibility, risk and probability also are explored. furthermore, the relevance of geotechnical research of slopes within the context of weather swap eventualities is mentioned. All concept is supported by way of a variety of examples.
''...A fabulous ebook on Slope Stability....recommended as a refernence ebook to people who are linked to the geotechnical engineering career (undergraduates, submit graduates and consulting engineers)...'' Prof. Devendra Narain Singh, Indian Inst. of know-how, Mumbai, India
''I have not begun to work out a publication that excels the diversity and intensity of Geotechnical Slope Analysis... i've got didn't discover a subject which isn't coated and that makes the ebook virtually a unmarried window outlet for the full diversity of readership from scholars to specialists and from theoreticians to practising engineers...'' Prof. R.K. Bhandari, New Delhi, India